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pentobarbital will reduce the level or outcome of vinorelbine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.pentobarbital will lower the extent or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with potent CYP3A4 inducers is just not su